NCI-006

• Target:

  ROS|||Others|||Apoptosis|||Dehydrogenase

• Related Pathways:

  Apoptosis|||Immunology/Inflammation|||Metabolism|||Others

• Bioactivity:

  NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.

• Smiles:

  C (C1=C (CC2CC2) N (N=C1C3=CC (C#CC=4SC (C) =CC4) =C (F) C=C3) C5=NC (C (O) =O) =CS5) C6=CC (F) =C (S (N) (=O) =O) C=C6

• Molecular Formula:

  C31H24F2N4O4S3

• Molecular Weight:

  650.74

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1964516-64-0