NCI-006

CAT: 0931-T70032-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T70032-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1964516-64-0
Target
ROS|||Others|||Apoptosis|||Dehydrogenase
Related Pathways
Apoptosis|||Immunology/Inflammation|||Metabolism|||Others
Bioactivity
NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.
Smiles
C(C1=C(CC2CC2)N(N=C1C3=CC(C#CC=4SC(C)=CC4)=C(F)C=C3)C5=NC(C(O)=O)=CS5)C6=CC(F)=C(S(N)(=O)=O)C=C6
Molecular Formula
C31H24F2N4O4S3
Molecular Weight
650.74
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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