NCI-006

• Target :

  ROS|||Others|||Apoptosis|||Dehydrogenase

• Related Pathways :

  Apoptosis|||Immunology/Inflammation|||Metabolism|||Others

• Bioactivity :

  NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.

• Smiles :

  C(C1=C(CC2CC2)N(N=C1C3=CC(C#CC=4SC(C)=CC4)=C(F)C=C3)C5=NC(C(O)=O)=CS5)C6=CC(F)=C(S(N)(=O)=O)C=C6

• Molecular Formula :

  C31H24F2N4O4S3

• Molecular Weight :

  650.74

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1964516-64-0