SWTX-143

• Target:

  YAP

• Related Pathways:

  Stem Cells

• Bioactivity:

  SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional activity of the YAP/TAZ-TEAD complex and demonstrating antitumor activity [1].

• Smiles:

  O=C(C=C)NC1CC=2C(N)=CC=CC2N(C3=CC=C(C=C3)C(F)(F)F)C1

• Molecular Formula:

  C19H18F3N3O

• Molecular Weight:

  361.36

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2766575-48-6