SWTX-143

• Target :

  YAP

• Related Pathways :

  Stem Cells

• Bioactivity :

  SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional activity of the YAP/TAZ-TEAD complex and demonstrating antitumor activity [1].

• Smiles :

  O=C(C=C)NC1CC=2C(N)=CC=CC2N(C3=CC=C(C=C3)C(F)(F)F)C1

• Molecular Formula :

  C19H18F3N3O

• Molecular Weight :

  361.36

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2766575-48-6