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M3-Huwentoxin IV

CAT: 0931-T80519-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T80519-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Sodium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
M3-Huwentoxin IV (m3-HwTx-IV) is a potent inhibitor of sodium channels (NaV), with half-maximal inhibitory concentrations (IC50s) of 3.3 nM for hNaV1.7, 6.8 nM for hNaV1.6, 7.2 nM for hNaV1.3, 8.4 nM for hNaV1.1, 11.9 nM for hNaV1.2, and 369 nM for hNaV1.4 in the QPatch assay. It also alleviates spontaneous pain in a rodent model induced by the NaV1.7 activator OD1 in a dose-dependent manner [1].
Molecular Formula
C170H271N53O46S6
Molecular Weight
3985.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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