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Huwentoxin-IV

CAT: 0931-TP2016Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2016Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
526224-73-7
Target
Sodium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM) . Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.
Molecular Formula
C174H278N52O51S6
Molecular Weight
4106.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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