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Lepadin E

CAT: 0931-T79638-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T79638-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
444914-19-6
Target
Glutathione Peroxidase, MDM-2/p53, Ferroptosis
Related Pathways
Apoptosis, Metabolism
Bioactivity
Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation while also augmenting ACSL4 expression, culminating in cell death. This compound exhibits a considerable antitumor effect [1].
Smiles
C(CCC[C@@H](CCC)O)[C@@H]1[C@]2([C@](N[C@@H](C)[C@H](OC(/C=C/CCCCC)=O)C2)(CCC1)[H])[H]
Molecular Formula
C26H47NO3
Molecular Weight
421.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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