Lepadin E

• Target:

  Glutathione Peroxidase|||MDM-2/p53|||Ferroptosis

• Related Pathways:

  Apoptosis|||Metabolism

• Bioactivity:

  Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation while also augmenting ACSL4 expression, culminating in cell death. This compound exhibits a considerable antitumor effect [1].

• Smiles:

  C(CCC[C@@H](CCC)O)[C@@H]1[C@]2([C@](N[C@@H](C)[C@H](OC(/C=C/CCCCC)=O)C2)(CCC1)[H])[H]

• Molecular Formula:

  C26H47NO3

• Molecular Weight:

  421.66

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  444914-19-6