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Anti-inflammatory agent 55

CAT: 0931-T79620-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T79620-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2924156-51-2
Target
TNF, NO Synthase, Interleukin, Others, NF-κB
Related Pathways
Others, Immunology/Inflammation, NF-κB, Apoptosis
Bioactivity
Compound 9j (anti-inflammatory agent 55), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of iNOS, TNF-α, IL-6, and IL-1β. It notably suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 0.8 μM and demonstrates anti-inflammatory effects in vivo using a mouse auricular edema model [1].
Smiles
O=[N+](C1=CC=C(O1)/C=C/C(NCCN2C3=CC=C(OC)C=C3OC2=O)=O)[O-]
Molecular Formula
C17H15N3O7
Molecular Weight
373.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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