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Anti-inflammatory agent 54

CAT: 0931-T79619-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T79619-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2924156-46-5
Target
NF-κB, Others, Interleukin, NO Synthase, TNF
Related Pathways
Apoptosis, NF-κB, Others, Immunology/Inflammation
Bioactivity
Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of pro-inflammatory cytokines such as iNOS, TNF-α, IL-6, and IL-1β. It effectively suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates in vivo efficacy in a mouse auricular edema model [1].
Smiles
C(CNC(/C=C/C1=CC=CO1)=O)N2C=3C(OC2=O)=CC(OC)=CC3
Molecular Formula
C17H16N2O5
Molecular Weight
328.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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