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Anticancer agent 154

CAT: 0931-T79388-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79388-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Reactive Oxygen Species, Apoptosis, Ferroptosis
Related Pathways
Immunology/Inflammation, NF-κB, Apoptosis, Metabolism
Bioactivity
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causes mitochondrial damage, and promotes cell apoptosis and DNA damage. It triggers ferroptosis by depleting GSH, diminishing GPX4 expression, and escalating lipid peroxidation. Additionally, it effectively suppresses the proliferation of various cancer cells (HT29, H1975, A549, and MCF-7) with IC50 values ranging from 1.0 to 1.9 μM [1].
Molecular Formula
C22H23N5O2
Molecular Weight
389.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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