Anticancer agent 147

• Target :

  Ferroptosis

• Related Pathways :

  Apoptosis

• Bioactivity :

  Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA), enhances endoplasmic reticulum (ER) stress, and upregulates activating transcription factor 3 (ATF3) expression, demonstrating potent anti-liver cancer effects both in vitro and in vivo [1].

• Smiles :

  C(CCC(OC)=O)[C@@H]1[C@@]2([C@@]3([C@@](CN1CC=4C=5C(N(CC6=CC=C(Br)C=C6)C4)=CC=CC5)(CCCN3CCC2)[H])[H])[H]

• Molecular Formula :

  C32H40BrN3O2

• Molecular Weight :

  578.58

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2241283-11-2