PD-L1-IN-3

CAT: 0931-T79314-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T79314-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2953044-29-4

Target

PD-1/PD-L1

Related Pathways

Cell Cycle/Checkpoint, Immunology/Inflammation, Apoptosis

Purity

0.9947

Bioactivity

PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1].

Smiles

[Cl].N#CC1=C(OCC2=CC=C(C=C2)CN)SC=C1C=3C=CC(F)=CC3

Molecular Formula

C19H15ClFN2OS

Molecular Weight

373.85

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

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HY-155101-01	PD-L1-IN-3
GTR19154165-01	PD-1/PD-L1-IN 3
B6191-1	PD-1/PD-L1 Inhibitor 3
HY-103048A-01	PD-1/PD-L1-IN 3 (TFA)
M30162	PD-1/PD-L1-IN 3 TFA
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PD-L1-IN-3

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