CYP51/PD-L1-IN-3

CYP51/PD-L1-IN-3

• CAS Number: 3032386-59-4
• UNSPSC Description: CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death[1].
• Target Antigen: Cytochrome P450; Fungal; PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/cyp51-pd-l1-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=NC2=CC=CC=C2C(N3C=NC=C3)=N1)NC4CCN(C(C5=CC=C(C(C)C)C=C5)=O)CC4
• Molecular Weight: 468.55
• References & Citations: [1]Sun B, et al. Design, Synthesis, and Activity Evaluation of Novel Dual-Target Inhibitors with Antifungal and Immunoregulatory Properties. J Med Chem. 2023 Sep 13.. .
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported