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Antibacterial agent 144

CAT: 0931-T79282-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79282-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Others, DNA/RNA Synthesis, Antibacterial
Related Pathways
Cell Cycle/Checkpoint, Microbiology/Virology, Others, DNA Damage/DNA Repair
Bioactivity
Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin. It acts by disrupting the bacterial cytoplasmic membrane and inhibiting biofilm formation. Additionally, it binds to human serum albumin (HSA) with a dissociation constant (Kd) of 13.2 μM, enhancing its bactericidal activity. This compound also forms a supramolecular complex with DNA, thereby hindering DNA replication [1].
Molecular Formula
C26H23N7O3
Molecular Weight
481.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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