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Antiproliferative agent-25

CAT: 0931-T79275-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79275-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, Histone Methyltransferase
Related Pathways
Apoptosis, Chromatin/Epigenetic
Bioactivity
Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM. It elevates hnRNP E1 protein levels and forms hydrogen bond interactions with SAM and the E444 residue of PRMT5. This compound exhibits antiproliferative effects in A549 cells by inducing apoptosis and inhibiting migration, albeit it presents high clearance rates, with half-lives of 21.8 minutes in human liver microsomes and 4.7 minutes in rat liver microsomes [1].
Molecular Formula
C20H21BrN2O2
Molecular Weight
401.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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