WM-586

• Target:

  Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding. It selectively reduces the interaction between WDR5 and MYC with an IC50 value of 101 nM, as determined by the HTRF assay [1].

• Smiles:

  FC1=C(C[C@@H](CCCC)C(=O)NC2=NN=NN2)C(F)=CC(C2C=CC=C(S(=O)(=O)F)C=2)=C1

• Molecular Formula:

  C20H20F3N5O3S

• Molecular Weight:

  467.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2894832-05-2