ACP-5862

• Target:

  BTK|||Drug Metabolite|||Cytochromes P450

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Metabolism|||Angiogenesis

• Bioactivity:

  ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for BTK) . Acalabrutinib is an irreversible and highly selective BTK inhibitor (IC50: 3 nM; EC50: 8 nM) .

• Smiles:

  CC#CC(=O)NCCCC(=O)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12

• Molecular Formula:

  C26H23N7O3

• Molecular Weight:

  481.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2230757-47-6