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WM-586

CAT: 0804-HY-153728-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153728-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WM-586 is a covalent WDR5 inhibitor. WM-586 specifically decreases WDR5 and MYC interaction with an IC50 of 101 nM. WM-586 is used in research on a variety of cancers including neuroblastoma, breast cancer, bladder cancer and colorectal cancer[1].
CAS Number
2894832-05-2
UNSPSC
12352005
Target
WDR5
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wm-586.html
Purity
98.74
Solubility
10 mM in DMSO
Smiles
FC1=C(C[C@H](CCCC)C(NC2=NN=NN2)=O)C(F)=CC(C3=CC(S(F)(=O)=O)=CC=C3)=C1
Molecular Formula
C20H20F3N5O3S
Molecular Weight
467.46
References & Citations
[1]Ding J, et al. Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. ACS Chem Biol. 2023 Jan 20;18 (1) :34-40.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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