SHP2-IN-22

• Target:

  Ras|||Others|||Phosphatase|||Kras

• Related Pathways:

  Others|||MAPK|||Metabolism

• Bioactivity:

  SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-2 pancreatic cancer cells. This compound is utilized in the study of Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research [1].

• Smiles:

  NC=1C(=NC=C(N1)N2CCN(C(NC3=CC(OC)=C(C#N)C=C3)=N)CC2)C4=C(Cl)C(Cl)=CC=C4

• Molecular Formula:

  C23H22Cl2N8O

• Molecular Weight:

  497.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2802453-88-7