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BWA-522

CAT: 0931-T78810-01Size: 5 mgDry Ice: NoHazardous: No
CAT#: T78810-01Size: 5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis|||Androgen Receptor
Related Pathways
Endocrinology/Hormones|||Apoptosis
Bioactivity
BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL) and the AR-V7 splice variant. It specifically antagonizes the N-terminal domain (AR-NTD) of the androgen receptor (Androgen Receptor), prompting apoptosis in prostate cancer (PC) cells. In LNCaP xenograft models, BWA-522 demonstrated tumor growth inhibition (60 mg/kg, po; TGI=76%) . The compound effectively reduced levels of AR-V7 and AR-FL by 77.3% at 1 ?M and 72.0% at 5 ?M, respectively, in VCaP and LNCaP cell lines [1].
Molecular Formula
C43H51ClN4O7
Molecular Weight
771.34
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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