673-A

• Target:

  Dehydrogenase|||Necroptosis|||Mitochondrial Metabolism|||Others

• Related Pathways:

  Apoptosis|||Metabolism|||Others

• Bioactivity:

  673-A is an aldehyde dehydrogenase (ALDH1A) inhibitor that depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. 673-A triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP) . 673-A also overcomes chemotherapy resistance in vivo.

• Smiles:

  O=CC1=CC=C (C=C1) N1CC2=CC=CC=C2C1

• Molecular Formula:

  C15H13NO

• Molecular Weight:

  223.27

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  109437-62-9