MY-1576

• Target:

  Hippo pathway|||FAK|||YAP

• Related Pathways:

  Stem Cells|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling

• Bioactivity:

  MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.

• Molecular Formula:

  C25H29ClN8O2

• Molecular Weight:

  509

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C