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SIK2-IN-3

CAT: 0931-T207716-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207716-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2810809-10-8
Target
SIK
Related Pathways
PI3K/Akt/mTOR signaling
Bioactivity
SIK2-IN-3 is an orally active selective inhibitor of SIK1/2 with IC50 values of 0.128/0.084 μM. It hinders the phosphorylation of CRTC3 and suppresses the production of pro-inflammatory factors in myeloid cells. Additionally, SIK2-IN-3 alleviates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model.
Smiles
O(C[C@@H]1CCN(C)C1)C=2C(=CC(C#N)=NC2)C3=CC=4N(C=C3)N=C(NC(=O)C5CC5)C4
Molecular Formula
C23H24N6O2
Molecular Weight
416.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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