SIK2-IN-3

• Target:

  SIK

• Related Pathways:

  PI3K/Akt/mTOR signaling

• Bioactivity:

  SIK2-IN-3 is an orally active selective inhibitor of SIK1/2 with IC50 values of 0.128/0.084 ?M. It hinders the phosphorylation of CRTC3 and suppresses the production of pro-inflammatory factors in myeloid cells. Additionally, SIK2-IN-3 alleviates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model.

• Smiles:

  O(C[C@@H]1CCN(C)C1)C=2C(=CC(C#N)=NC2)C3=CC=4N(C=C3)N=C(NC(=O)C5CC5)C4

• Molecular Formula:

  C23H24N6O2

• Molecular Weight:

  416.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2810809-10-8