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Anticancer agent 164

CAT: 0931-T78608-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T78608-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2235393-30-1
Target
Apoptosis, MEK, PI3K
Related Pathways
PI3K/Akt/mTOR signaling, Apoptosis, MAPK
Bioactivity
CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid leukemia (CML) cell line K562. It diminishes protein phosphorylation within the PI3K/Akt signaling pathway to exert its effects and suppresses cell proliferation through the inhibition of the MEK/ERK signaling pathway in colorectal cancer [1] [2].
Smiles
S(C=1SC(NC(NC2=CC=C(C(F)(F)F)C=C2)=O)=NN1)C=3C=C(NCCCN4CCOCC4)N=CN3
Molecular Formula
C21H23F3N8O2S2
Molecular Weight
540.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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