JAK-IN-25

• Target:

  JAK

• Related Pathways:

  JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||Stem Cells

• Bioactivity:

  JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. It also demonstrates an IC50 of 28 nM against human whole blood IL-12 (HEB IL-12) and holds potential for cancer research [1].

• Smiles:

  O=C(OC)C1=NN2C=C(NC(=O)C2=C1)C=3C=NN(C3)CC4=CC=C(OC)C=C4

• Molecular Formula:

  C19H17N5O4

• Molecular Weight:

  379.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2127110-22-7