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JAK-IN-25

CAT: 0931-T78175-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T78175-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2127110-22-7
Target
JAK
Related Pathways
JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Stem Cells
Bioactivity
JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. It also demonstrates an IC50 of 28 nM against human whole blood IL-12 (HEB IL-12) and holds potential for cancer research [1].
Smiles
O=C(OC)C1=NN2C=C(NC(=O)C2=C1)C=3C=NN(C3)CC4=CC=C(OC)C=C4
Molecular Formula
C19H17N5O4
Molecular Weight
379.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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