JAK-IN-25

• Target :

  JAK

• Related Pathways :

  JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||Stem Cells

• Bioactivity :

  JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. It also demonstrates an IC50 of 28 nM against human whole blood IL-12 (HEB IL-12) and holds potential for cancer research [1].

• Smiles :

  O=C(OC)C1=NN2C=C(NC(=O)C2=C1)C=3C=NN(C3)CC4=CC=C(OC)C=C4

• Molecular Formula :

  C19H17N5O4

• Molecular Weight :

  379.37

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2127110-22-7