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JAK-IN-20

CAT: 0931-T63581-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63581-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1654776-91-6
Target
Others, JAK
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling, Others, Stem Cells
Bioactivity
JAK-IN-20 is a potent, orally active, broad-based JAK inhibitor, effective on JAK1 (IC50: 7 nM), JAK2 (IC50: 5 nM), and JAK3 (IC50: 14 nM), exhibiting excellent pharmacokinetic and anti-inflammatory activity in vivo.
Smiles
FC=1C(=NC(NC2=CC=C(C=C2)N3CCC(CC3)N4CCOCC4)=NC1)C5=CC=C(C(NCC#N)=O)C=C5
Molecular Formula
C28H30FN7O2
Molecular Weight
515.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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