JAK-IN-20

• Target:

  Others|||JAK

• Related Pathways:

  Angiogenesis|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||JAK/STAT signaling|||Others|||Stem Cells

• Bioactivity:

  JAK-IN-20 is a potent, orally active, broad-based JAK inhibitor, effective on JAK1 (IC50: 7 nM), JAK2 (IC50: 5 nM), and JAK3 (IC50: 14 nM), exhibiting excellent pharmacokinetic and anti-inflammatory activity in vivo.

• Smiles:

  FC=1C(=NC(NC2=CC=C(C=C2)N3CCC(CC3)N4CCOCC4)=NC1)C5=CC=C(C(NCC#N)=O)C=C5

• Molecular Formula:

  C28H30FN7O2

• Molecular Weight:

  515.58

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1654776-91-6