TP-1454

CAT: 0931-T77775-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T77775-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2490276-04-3

Target

Others, PKM

Related Pathways

Metabolism, Others

Bioactivity

TP-1454 is an activator against PKM2 with a biochemically determined AC50 of 10 Nm. It can regulate tumor immune responses by acting on T regulatory cells.

Smiles

N(C(=O)C1=CC(C(F)(F)F)=NN1)(CC2=C(F)C=CC=C2N)CCC3CCS(=O)(=O)CC3

Molecular Formula

C19H22F4N4O3S

Molecular Weight

462.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

PKM2 activator 10

CAS Number	2490276-04-3
PubChem CID	90120714
IUPAC Name	N-[(2-amino-6-fluorophenyl)methyl]-N-[2-(1,1-dioxothian-4-yl)ethyl]-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide
Molecular Formula	C19H22F4N4O3S
Molecular Weight	462.5
XLogP	2.3
Topological Polar Surface Area	118
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Heavy Atom Count	31
Formal Charge	0
Complexity	717

SMILES

C1CS(=O)(=O)CCC1CCN(CC2=C(C=CC=C2F)N)C(=O)C3=NNC(=C3)C(F)(F)F

InChI

InChI=1S/C19H22F4N4O3S/c20-14-2-1-3-15(24)13(14)11-27(7-4-12-5-8-31(29,30)9-6-12)18(28)16-10-17(26-25-16)19(21,22)23/h1-3,10,12H,4-9,11,24H2,(H,25,26)

InChIKey

GASMZUDGPKMAEI-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2490276-04-3

CID: 90120714

Formula: C19H22F4N4O3S

MW: 462.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	462.5
XLogP3	2.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Exact Mass	462.13487440
Monoisotopic Mass	462.13487440
Topological Polar Surface Area	118 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	717
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
C01620-01	TP-1454
BA4814-5	TP-064
BA3828-1	TP-1287
BA7972-5	TP-004
B7976-.1	Xanthosine-TP
BA6395-100	TP-3654
BA1839-1	FNC-TP
BA8170-5	TP-10
FID30620-01	TP 064
FT137729-01	TP 0903

TP-1454

Chemical Information

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