ROS-generating agent 1

CAT: 0931-T77762-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T77762-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2369030-41-9

Target

Reactive Oxygen Species, Ferroptosis, Apoptosis, ROS Kinase, ROS

Related Pathways

Immunology/Inflammation, NF-κB, Tyrosine Kinase/Adaptors, Apoptosis, Metabolism

Purity

0.9976

Bioactivity

Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR. ROS-generating agent 1 reduces intracellular TrxR protein levels and promotes ROs-dependent apoptosis and ferroptosis in NCI-H460 cells.

Smiles

C(=C\1/C(=O)\C(=C\C2=CC(C(F)(F)F)=CC=C2)\CNC1)\C3=CC(C(F)(F)F)=CC=C3

Molecular Formula

C21H15F6NO

Molecular Weight

411.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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