JC2-11

CAT: 0931-T77579-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T77579-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

937820-89-8

Target

NOD-like Receptor (NLR), AIM2, IL Receptor, Caspase, Dehydrogenase, ROS

Related Pathways

Immunology/Inflammation, Metabolism, Apoptosis, Proteases/Proteasome

Purity

0.9988

Bioactivity

JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles.

Smiles

C(/C=C/C1=CC(OC)=C(O)C=C1)(=O)C2=CC(F)=C(OC)C=C2

Molecular Formula

C17H15FO4

Molecular Weight

302.3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
BA5837-100	JC2-11
GTR17858433	Mouse p16 INK4, clone JC2 (Monoclonal) Antibody
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BUP12606-01	11ß-HSD1-IN-11
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B688439	1-Bromoundecane-11,11,11-d3
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