Malantide TFA

• Target:

  PKA|||PKC

• Related Pathways:

  Chromatin/Epigenetic|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors

• Bioactivity:

  Malantide TFA, a synthetic dodecapeptide, originates from the phosphorylation site targeted by cAMP-dependent protein kinase (PKA) on the ?-subunit of phosphorylase kinase. Exhibiting a high specificity for PKA with a Michaelis constant (Km) of 15 ?M, this compound demonstrates more than 90% inhibition of substrate phosphorylation in the presence of protein inhibitor (PKI) across various rat tissue extracts [1]. Moreover, Malantide TFA acts as an effective substrate for Protein Kinase C (PKC) with a Km of 16 ?M [2].

• Molecular Formula:

  C74H125F3N22O23

• Molecular Weight:

  1747.91

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C