Spadin TFA

• Target :

  5-HT Receptor|||Potassium Channel

• Related Pathways :

  GPCR/G Protein|||Neuroscience|||Membrane transporter/Ion channel

• Bioactivity :

  Spadin TFA, a natural peptide originating from a propeptide in blood, acts as a powerful TREK-1 channel inhibitor with an IC 50 of 10 nM. It boosts dorsal raphe nucleus 5-HT neurotransmission in mice, activates hippocampal CREB, and promotes neurogenesis. This compound is useful for antidepressant research [1] [2].

• Molecular Formula :

  C92H143F3N26O24

• Molecular Weight :

  2126.36

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C