Decapeptide-12

• Target:

  Tyrosinase|||Sirtuin

• Related Pathways:

  Proteases/Proteasome|||DNA Damage/DNA Repair|||Chromatin/Epigenetic

• Bioactivity:

  Decapeptide-12, a competitive inhibitor of mushroom tyrosinase with an IC50 of 40 µM and a Kd of 61.1 ?M for the C-terminal residue of tyrosinase, is a small oligopeptide that reduces melanin content in melanocytes by interacting with tyrosinase and increasing transcription of SIRT. It is utilized in researching melanogenesis, senescence, and inflammation [1] [2] [3].

• Smiles:

  C ([C@@H] (C (N[C@@H] (CC1=CC=C (O) C=C1) C (O) =O) =O) NC ([C@@H] (NC ([C@@H] (NC ([C@H] (CC2=CC=C (O) C=C2) NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@H] (CC3=CC=C (O) C=C3) N) =O) CCCNC (=N) N) =O) CO) =O) CCCNC (=N) N) =O) CCCCN) =O) =O) CO) =O) CO) =O) C=4C=5C (NC4) =CC=CC5

• Molecular Formula:

  KS3WY3

• Molecular Weight:

  1395.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  137665-91-9