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Nampt degrader-2

CAT: 0931-T75023-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T75023-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PROTACs, NAMPT, Others
Related Pathways
Metabolism, PROTAC, Others
Bioactivity
Nampt degrader-2, a fluorescent PROTAC, exhibits efficient degradation of NAMPT at an IC50 of 41.9 nM. It operates by binding to both NAMPT and VHL, initiating the formation of a ternary complex that triggers NAMPT degradation through the ubiquitin-proteasome system (UPS) . This activity significantly lowers NAD+ levels and displays potent antitumor effects [1].
Molecular Formula
C59H73N9O7S
Molecular Weight
1052.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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