Products for Research Use Only
RegisterLogin

MS9449

CAT: 0931-T74635-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T74635-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2772612-96-9
Target
EGFR, PROTACs
Related Pathways
PROTAC, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
MS9449 is a potent PROTAC EGFR degrader, exhibiting dissociation constants (Kd) of 17 nM for EGFR WT and 10 nM for EGFR L858R. It effectively mediates the degradation of mutant EGFRs via both ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways, robustly suppressing the proliferation of NSCLC cells, indicating its potential utility in anticancer research [1].
Smiles
N(C=1C2=C(C=C(OC)C(OCCCN3CCN(C(CCCCCCCCCCNC(C[C@H](NC(=O)[C@H]4N(C([C@H]([C@H](C)C)C=5ON=C(C)C5)=O)C[C@H](O)C4)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)=O)CC3)=C2)N=CN1)C8=CC(Cl)=C(F)C=C8
Molecular Formula
C60H76ClFN10O8S
Molecular Weight
1151.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T74633-01MS9427
T79143-01MS934
T74634-01MS9427 TFA

Alternative Products

CatalogName
HY-147942-01MS9449
A24093-10MS9449 10mg
A24093-50MS9449 50mg
A24093-1MS9449 1mg
A24093-5MS9449 5mg

Popular Products