JPS014

• Target :

  PROTACs|||Others|||HDAC

• Related Pathways :

  Others|||DNA Damage/DNA Repair|||PROTAC|||Chromatin/Epigenetic

• Bioactivity :

  JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].

• Smiles :

  Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCOCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2N)C(C)(C)C)cc1

• Molecular Formula :

  C46H59N7O7S

• Molecular Weight :

  854.07

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2669785-76-4