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JPS014

CAT: 0804-HY-145815Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145815Size:1 Each
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Description
JPS014 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC) . JPS014 degrades class I histone deacetylase (HDAC) . JPS014 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
CAS Number
2669785-76-4
UNSPSC
12352005
Target
HDAC; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jps014.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCCCCCCCOCC(NC4=CC=C(C(NC5=CC=CC=C5N)=O)C=C4)=O
Molecular Formula
C46H59N7O7S
Molecular Weight
854.07
References & Citations
[1]Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65 (7) :5642-5659.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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