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JPS035

CAT: 0931-T74455-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74455-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2669785-84-4
Target
PROTACs, Others, HDAC
Related Pathways
DNA Damage/DNA Repair, Others, PROTAC, Chromatin/Epigenetic
Bioactivity
JPS035, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), specifically HDAC1/2. Its potent activity is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].
Smiles
CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1OCCCCCCCCCCCC(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1N)-c1scnc1C)C(C)(C)C
Molecular Formula
C49H65N7O7S
Molecular Weight
896.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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