β-Glucuronide-dPBD-PEG5-NH2 TFA

CAT: 0931-T74438-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T74438-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2246364-63-4

Target

Drug-Linker Conjugates for ADC, Apoptosis

Related Pathways

Antibody-drug Conjugate/ADC Related, Apoptosis

Bioactivity

β-Glucuronide-dPBD-PEG5-NH2 TFA is a β-glucuronide-linked pyrrolobenzodiazepine dimer used in the synthesis of the antibody-drug conjugate (ADC) cIRCR201-dPBD, employing a cleavable β-glucuronide linkage. It serves as a proagent to reduce side effects, induce apoptosis, and arrest the cell cycle, exhibiting antitumor activity [1].

Smiles

OC(=O)C(F)(F)F.[H][C@@]12CC(=C)CN1C(=O)c1cc(OC)c(OCCCCCOc3cc4N(C(O)[C@]5([H])CC(=C)CN5C(=O)c4cc3OC)C(=O)OCc3ccc(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)c(c3)C(=O)NCCOCCOCCOCCOCCOCCON)cc1N(C2O)C(=O)OCc1ccc(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)c(c1)C(=O)NCCOC

Molecular Formula

C80H102F3N7O37

Molecular Weight

1810.69

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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β-Glucuronide-dPBD-PEG5-NH2 TFA

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