β-Glucuronide-dPBD-PEG5-NH2

• Description:

  β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity[1].

• UNSPSC:

  12352203

• Target:

  Apoptosis; Drug-Linker Conjugates for ADC

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/β-glucuronide-dpbd-peg5-nh2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NOCCOCCOCCOCCOCCOCCNC (C (C=C1COC (N2C3=CC (OCCCCCOC4=C (OC) C=C (C (N5[C@] (CC (C5) =C) ([H]) C (N6C (OCC7=CC (C (NCCOC) =O) =C (C=C7) O[C@@H]8O[C@@H] ([C@H] ([C@@H] ([C@H]8O) O) O) C (O) =O) =O) O) =O) C6=C4) =C (OC) C=C3C (N9[C@] (CC (C9) =C) ([H]) C2O) =O) =O) =C (C=C1) O[C@@H]%10O[C@@H] ([C@H] ([C@@H] ([C@H]%10O) O) O) C (O) =O) =O

• Molecular Formula:

  C78H101N7O35

• Molecular Weight:

  1696.66

• References & Citations:

  [1]Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5 (40) :25798-25809.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• CAS Number:

  2246363-68-6