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β-Glucuronide-dPBD-PEG5-NH2

CAT: 0931-T74437-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74437-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2246363-68-6
Target
Apoptosis, Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related, Apoptosis
Bioactivity
β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugate (ADC) cIRCR201-dPBD, utilizing a cleavable β-glucuronide linkage. This compound targets and binds to the prenylated antibody, facilitating controlled drug release to mitigate side effects and exhibits antitumor properties by inducing apoptosis and arresting the cell cycle [1].
Smiles
[H][C@@]12CC(=C)CN1C(=O)c1cc(OC)c(OCCCCCOc3cc4N(C(O)[C@]5([H])CC(=C)CN5C(=O)c4cc3OC)C(=O)OCc3ccc(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)c(c3)C(=O)NCCOCCOCCOCCOCCOCCON)cc1N(C2O)C(=O)OCc1ccc(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)c(c1)C(=O)NCCOC
Molecular Formula
C78H101N7O35
Molecular Weight
1696.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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