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Cis-Lomibuvir

CAT: 0931-T73814-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T73814-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1026785-59-0
Target
DNA/RNA Synthesis, Others, HCV Protease
Related Pathways
Proteases/Proteasome, Others, DNA Damage/DNA Repair, Microbiology/Virology, Cell Cycle/Checkpoint
Bioactivity
Cis-Lomibuvir (cis-VX-222), a cis-isomer of Lomibuvir, is a selective non-nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase (RdRp), targeting thumb pocket 2 with a dissociation constant (Kd) of 17 nM. It exhibits an EC50 of 5.2 nM against the 1b/Con1 HCV subgenomic replicon, demonstrating a preference for inhibiting elongative RNA synthesis over de novo-initiated RNA synthesis.
Smiles
C[C@H]1CC[C@@H](CC1)C(=O)N([C@@H]1CC[C@@H](CC1)O)c1c(sc(c1)C#CC(C)(C)C)C(=O)O
Molecular Formula
C25H35NO4S
Molecular Weight
445.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
MBS5815881cis-Lomibuvir
A10980-50Cis-Lomibuvir (cis-VX-222) 50mg
A10980-10Cis-Lomibuvir (cis-VX-222) 10mg
A10980-100Cis-Lomibuvir (cis-VX-222) 100mg
A10980-25Cis-Lomibuvir (cis-VX-222) 25mg
A10980-5Cis-Lomibuvir (cis-VX-222) 5mg
A10980-10mM-DCis-Lomibuvir (cis-VX-222) 10mM * 1mL in DMSO
HY-75800-01Lomibuvir
HY-75800R-01Lomibuvir (Standard)
C16340-50mgLomibuvir (VX-222)

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