I-138

• Target:

  DUB

• Related Pathways:

  Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Ubiquitination

• Purity:

  0.9941

• Bioactivity:

  I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.

• Smiles:

  C(N1C=2C(NC1=O)=CN=C(N2)C3=C(C(C)C)C=CC=C3)C4=CC=C(C=C4)C5=NC(C(F)(F)F)=CN5C

• Molecular Formula:

  C26H23F3N6O

• Molecular Weight:

  492.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2098211-50-6