ADH-6

• Target :

  Others|||MDM-2/p53|||Apoptosis

• Related Pathways :

  Others|||Apoptosis

• Bioactivity :

  ADH-6, a tripyridylamide compound, impedes the self-assembly of the aggregation-nucleating subdomain of mutant p53 DNA-binding domain (DBD) . By targeting and dissociating mutant p53 aggregates in human cancer cells, ADH-6 reinstates p53's transcriptional activity, culminating in cell cycle arrest and apoptosis, thereby holding potential for cancer research.

• Smiles :

  N(C(=O)C=1N=C(OCCCC)C(N(=O)=O)=CC1)C2=C(OCCCN)N=C(C(NC3=C(OCCCN)N=C(C(OC)=O)C=C3)=O)C=C2

• Molecular Formula :

  C29H36N8O9

• Molecular Weight :

  640.64

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2227429-65-2