YLT-11

• Target:

  Apoptosis|||PLK|||Others

• Related Pathways:

  Apoptosis|||Others|||Cell Cycle/Checkpoint

• Bioactivity:

  YLT-11 is a potent, selective, and orally active inhibitor of polo-like kinase 4 (PLK4), with dissociation constant (Kd) values of >10000 nM for PLK1, 653 nM for PLK2, >10000 nM for PLK3, and 5.2 nM for PLK4. It demonstrates antiproliferative effects, induces apoptosis, and causes cell cycle arrest at the G2/M phase, highlighting its anticancer activity.

• Smiles:

  CC(=O)NC1=NC=CC(=N1)C2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=C(C=C4)CN(C)C

• Molecular Formula:

  C24H24N6O

• Molecular Weight:

  412.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C