EDP-305

• Target :

  FXR|||Phosphatase|||Cytochromes P450|||Others

• Related Pathways :

  Others|||Metabolism

• Bioactivity :

  EDP-305, an orally active, potent, and selective agonist of the farnesoid X receptor (FXR), exhibits EC50 values of 34 nM in chimeric FXR within CHO cells and 8 nM in full-length FXR in HEK cells. Demonstrating a potent and consistent antifibrotic effect, EDP-305 is utilized in research related to primary biliary cholangitis (PBC) and non-alcoholic steatohepatitis (NASH) .

• Smiles :

  O[C@H]1[C@@]2([C@@]([C@]3(C)[C@]([C@H]1CC)(C[C@H](O)CC3)[H])(CC[C@@]4(C)[C@]2(CC[C@@]4([C@@H](CCNC(NS(=O)(=O)C5=CC=C(C(C)(C)C)C=C5)=O)C)[H])[H])[H])[H]

• Molecular Formula :

  C36H58N2O5S

• Molecular Weight :

  630.92

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1933507-63-1