IDH-305

• Target :

  Isocitrate Dehydrogenase (IDH) |||Dehydrogenase

• Related Pathways :

  Metabolism

• Purity :

  0.9968

• Bioactivity :

  IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively.

• Smiles :

  C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1

• Molecular Formula :

  C23H22F4N6O2

• Molecular Weight :

  490.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1628805-46-8