IDH-305

• Target:

  Isocitrate Dehydrogenase (IDH) |||Dehydrogenase

• Related Pathways:

  Metabolism

• Purity:

  0.9968

• Bioactivity:

  IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively.

• Smiles:

  C[C@H] (F) [C@H]1COC (=O) N1c1ccnc (N[C@@H] (C) c2cc (C) c (cn2) -c2ccnc (c2) C (F) (F) F) n1

• Molecular Formula:

  C23H22F4N6O2

• Molecular Weight:

  490.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1628805-46-8