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IDH-305

CAT: 0931-T15550-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T15550-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1628805-46-8
Target
Isocitrate Dehydrogenase (IDH), Dehydrogenase
Related Pathways
Metabolism
Purity
0.9968
Bioactivity
IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively.
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C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1
Molecular Formula
C23H22F4N6O2
Molecular Weight
490.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
DQC80546-01IDH 305
BUP04418-01IDH-305
A16943-10IDH-305 10mg
A16943-5IDH-305 5mg
A16943-1IDH-305 1mg
A16943-2IDH-305 2mg
A16943-25IDH-305 25mg
A16943-100IDH-305 100mg
A16943-50IDH-305 50mg
A16943-10mM-DIDH-305 10mM * 1mL in DMSO

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