EIF4A3-IN-9

CAT: 0931-T73001-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0931-T73001-02Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1402931-71-8

Target

Others, PERK

Related Pathways

Apoptosis, Others

Bioactivity

EIF4A3-IN-9, a silvestrol analogue, disrupts the assembly of the eIF4F translation complex, exhibiting EC50 values of 29, 450, and 80 nM for myc-LUC, tub-LUC, and growth inhibition in MBA-MB-231 cells, respectively. It is utilized in researching human cancer pathogenesis [1].

Smiles

O[C@]12[C@]([C@@H]([C@@H](C(OC)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(C(N)=O)C4)C5=CC=C(OC)C=C5

Molecular Formula

C28H27NO8

Molecular Weight

505.52

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

eIF4A3-IN-9

CAS Number	1402931-71-8
PubChem CID	71460662
IUPAC Name	methyl (1R,2R,3S,3aR,8bS)-6-carbamoyl-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate
Molecular Formula	C28H27NO8
Molecular Weight	505.5
XLogP	2.1
Topological Polar Surface Area	138
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Heavy Atom Count	37
Formal Charge	0
Complexity	855

SMILES

COC1=CC=C(C=C1)[C@]23[C@@H]([C@H]([C@H]([C@]2(C4=C(O3)C=C(C=C4OC)C(=O)N)O)O)C(=O)OC)C5=CC=CC=C5

InChI

InChI=1S/C28H27NO8/c1-34-18-11-9-17(10-12-18)28-22(15-7-5-4-6-8-15)21(26(32)36-3)24(30)27(28,33)23-19(35-2)13-16(25(29)31)14-20(23)37-28/h4-14,21-22,24,30,33H,1-3H3,(H2,29,31)/t21-,22-,24-,27+,28+/m1/s1

InChIKey

NDSAJVZNWSEAEP-BIKHGDPZSA-N

Chemical Structure

2D Structure

CAS: 1402931-71-8

CID: 71460662

Formula: C28H27NO8

MW: 505.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	505.5
XLogP3	2.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Exact Mass	505.17366682
Monoisotopic Mass	505.17366682
Topological Polar Surface Area	138 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	855
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T62884-01	EIF4A3-IN-6
T11170-01	EIF4A3-IN-1
T62161-01	EIF4A3-IN-4
T72746-01	(R) -eIF4A3-IN-2
TMAB-05515-01	Anti-eIF4A3 Antibody (1Y205)

Alternative Products

Catalog	Name
HY-148443-01	EIF4A3-IN-9
561305-01	EIF4A3
BA3611-10	eIF4A3-IN-2
BA4099-250	eIF4A3-IN-8
BA4096-10	eIF4A3-IN-1
HY-148444-01	EIF4A3-IN-10
HY-148446	EIF4A3-IN-12
HY-148450	EIF4A3-IN-16
HY-145361	EIF4A3-IN-7
561307-01	EIF4A3 (FITC)

EIF4A3-IN-9

Chemical Information

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