EIF4A3-IN-18

• Target :

  PERK|||Others

• Related Pathways :

  Apoptosis|||Others

• Bioactivity :

  EIF4A3-IN-18, a silvestrol analogue, disrupts the formation of the eIF4F translation complex, exhibiting EC 50 values of 0.8, 35, and 2 nM for myc-LUC, tub-LUC, and the growth inhibition of MBA-MB-231 cells, respectively. Additionally, it demonstrates cytotoxicity towards RMPI-8226 cells with an LC 50 of 0.06 nM. This compound is utilized in researching human cancer pathogenesis [1].

• Smiles :

  O[C@]12[C@]([C@@H]([C@@H](C(N(C)C)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(C#N)C4)C5=CC=C(OC)C=C5

• Molecular Formula :

  C29H28N2O6

• Molecular Weight :

  500.54

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1402931-84-3