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EIF4A3-IN-18

CAT: 0931-T72944-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72944-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1402931-84-3
Target
PERK, Others
Related Pathways
Apoptosis, Others
Bioactivity
EIF4A3-IN-18, a silvestrol analogue, disrupts the formation of the eIF4F translation complex, exhibiting EC 50 values of 0.8, 35, and 2 nM for myc-LUC, tub-LUC, and the growth inhibition of MBA-MB-231 cells, respectively. Additionally, it demonstrates cytotoxicity towards RMPI-8226 cells with an LC 50 of 0.06 nM. This compound is utilized in researching human cancer pathogenesis [1].
Smiles
O[C@]12[C@]([C@@H]([C@@H](C(N(C)C)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(C#N)C4)C5=CC=C(OC)C=C5
Molecular Formula
C29H28N2O6
Molecular Weight
500.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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BA3611-10eIF4A3-IN-2
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