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KRAS inhibitor-3

CAT: 0931-T72659-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72659-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
900897-56-5
Target
Others, Kras, Ras
Related Pathways
Others, MAPK, GPCR/G Protein
Bioactivity
KRAS inhibitor-3, an efficacious inhibitor of both wild-type (WT) and oncogenic KRAS mutations, exhibits high-affinity binding (K D: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, and 0.74 μM for KRAS Q61H) . Additionally, it impedes the interaction between KRAS and Raf, highlighting its potential as a targeted therapeutic agent in KRAS-mutant cancers.
Smiles
Cc1nn2c(cc(nc2c1-c1ccccc1)-c1ccccc1)N1CCN(CCO)CC1
Molecular Formula
C25H27N5O
Molecular Weight
413.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-122914-01KRAS inhibitor-3
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MBS5815894KRAS G12D Inhibitor 3 TFA
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A13018-25KRas G12C inhibitor 3 25mg
A13018-10KRas G12C inhibitor 3 10mg

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