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Anticancer agent 58

CAT: 0931-T72475-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72475-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Others, Apoptosis, Caspase, ROS Kinase
Related Pathways
Others, Tyrosine Kinase/Adaptors, Apoptosis, Proteases/Proteasome
Bioactivity
Anticancer agent 58 exhibits inhibitory activity against various cancer cell lines, particularly A549 and T24, with IC50 values of 0.6 μM and 0.7 μM, respectively. It promotes apoptosis through the activation of caspase 3/8/9, and elevates levels of Ca2+ and ROS within cancer cells. Additionally, it significantly reduces mitochondrial membrane potential and suppresses tumor growth in the T24 mouse xenograft model.
Smiles
C[C@]12CC[C@](C[C@H]1C3=CC(=O)C4[C@]5(CC[C@@H](C(C5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)[C@H](CC6=CC=CC=C6)N)C)(C)C(=O)O
Molecular Formula
C39H55NO5
Molecular Weight
617.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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