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STA-1474

CAT: 0931-T71426-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T71426-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1118915-78-8
Target
Others
Related Pathways
Others
Bioactivity
STA-1474 is a water soluble prodrug of ganetespib (formerly STA-9090) . STA-1474 will metabolized to Ganetespib, which is a potent HSP90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibit tumor growth in the setting of murine xenografts. The purpose of the following study was to extend these observations and investigate the safety and efficacy of STA-1474 in dogs with spontaneous tumors.
Smiles
O=C1N(C(=NN1)C2=CC(C(C)C)=C(OP(=O)(O)O)C=C2O)C=3C=C4C(=CC3)N(C)C=C4
Molecular Formula
C20H21N4O6P
Molecular Weight
444.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Sta-1474

antineoplastic agent

CAS Number1118915-78-8
PubChem CID135565962
IUPAC Name[5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate
Molecular FormulaC20H21N4O6P
Molecular Weight444.4
XLogP1.8
Topological Polar Surface Area137
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity773
SMILES
CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)OP(=O)(O)O
InChI
InChI=1S/C20H21N4O6P/c1-11(2)14-9-15(17(25)10-18(14)30-31(27,28)29)19-21-22-20(26)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25H,1-3H3,(H,22,26)(H2,27,28,29)
InChIKey
JNWFIPVDEINBAI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sta-1474
CAS: 1118915-78-8
CID: 135565962
Formula: C20H21N4O6P
MW: 444.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight444.4
XLogP31.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass444.11987140
Monoisotopic Mass444.11987140
Topological Polar Surface Area137 Ų
Heavy Atom Count31
Formal Charge0
Complexity773
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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