CIB-1476

CAT: 0931-T200261-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T200261-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

NOD-like Receptor (NLR), NF-κB, Pyroptosis, Caspase

Related Pathways

Immunology/Inflammation, NF-κB, Apoptosis, Proteases/Proteasome

Bioactivity

CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.

Molecular Formula

C28H28N2O6S

Molecular Weight

520.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-169018	CIB-1476
267739-01	CIB
2332616	AE-1476 EzBlock BSA
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sc-65998	CIB (5A1H7E12)
sc-271041	CIB (E-9)
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